Thailand FDA approved registration # 1C 199/51 – Approved October 10th 2008
- Declining physical activity and mental alertness in middle-aged and old men.
- Hypogonadism , potency disturbances due to androgen deficiency
- Infertility, Oligozoospermia, increased sperm count, improved quality and sperm motility.
CAS Name: (1a,5a,17b)-17-Hydroxy-1-methylandrostan-3-one
Additional Names: 1a-methyl-5a-androstan-17b-ol-3-one; 1a-methyl-5a-dihydrotestosterone
Molecular Formula: C20H32O2
Molecular Weight: 304.47.
Percent Composition: C 78.90%, H 10.59%, O 10.51%
Melting point: mp 203.5-205.0°
Optical Rotation: [a]D20 +17.6° (c = 0.875 in CHCl3)
Each uncoated tablet contains:
MesteroloneÂ 25 mg
Mesviron 25 tablet contains 25mg of the androgen Mesterolone.
Mesterolone balances a deficiency of androgen formation, which begins to fall gradually with increasing age. Therefore, Mesterolone is suitable for treatment of all conditions caused by deficient endogenous androgen formation. In the recommended therapeutic dosage, Mesterolone will not impair spermatogenesis. Mesterolone is especially well tolerated by the liver.
INDICATIONS AND USES
- Declining physical activity and mental alertness in middle and old aged men.
Reduced efficiency, easy fatigability, lack of concentration, weak memory, disturbances of libido and potency, irritability, disturbances of sleep, depressive moods, and general vegetative complaints are often attributed to androgen-deficiency. These complaints can be overcome or improved by the use of Mesviron 25 tablets.
- Potency disturbances
Mesviron 25 overcomes potency disturbances due to androgen-Âdeficiency. It may also be of use as supplementary therapy in cases of diminished potency where androgen-deficiency is not the primary cause.
Growth, development, and function of androgen-dependent target organs are stimulated by Mesviron 25. It promotes development of secondary male sex characteristics in cases of prepuberal hypogonadism. Full clinical and laboratory investigations are necessary in all cases of young patients prior to commencement of treatment. Mesviron 25 may also be used as a substitution therapy in cases where a loss of gonadal function has occurred postpuberally.
Oligozoospermia and deficient Leydig-cell secretion may be the cause of infertility. With Mesterolone treatment, sperm count can be increased, the quality improved and, furthermore, a higher fructose concentration up to normal values can be achieved thus increasing the chances of procreation.
In-patients with carcinoma of the prostate, androgen therapy of any kind, including the use of Mesviron 25 is contraindicated.
The administration of Mesviron 25 is recommended only for male patients.
Regular examinations of the prostate should be carried out prophylactically.
DOSAGE AND ADMINISTRATION
As directed by a physician. The following dosage may be recommended:
- In declining physical activity and potency disturbances
Commencement of treatment: One tablet of Mesviron 25 three times daily.
Continuation of treatment: One tablet of Mesviron 25 twice or once daily.
According to type and severity of the complaints, a course of Mesviron 25 lasting four to six weeks or a prolonged uninterrupted treatment over several months is recommended. If required, the course of treatment may be repeated several times.
- Hypogonadism requires continuous therapy
For development of secondary male sex characteristics one tablet of Mesviron 25 3-4 times daily for several months. As maintenance dose, one tablet of Mesviron 25 twice or three times daily will be sufficient.
- In Oligozoospermia
One tablet of Mesviron 25 twice or three times daily for a cycle of spermatogenesis, i.e. 9O days.
In case of simultaneously impaired gonadotrophic excretion, a combined therapy with gonadotrophic hormone exhibiting FSH activity is recommended for the commencement of treatment (e.g. 2000 IU serum gonadotrophin IM twice weekly up to a total amount of 12 000 IU). If necessary, treatment with Mesviron 25 is to be repeated after an interval of several weeks.
25 mg scored tablets in blister packs of 10 tablets – 5 packs per box (50 tablets)
Formerly presented in bottles of 100 tablets of 25mg (bottles discontinued)
Store in a cool dry place. Protect from light.
Manufactured by: Unigen Life Sciences Co. Ltd.